Plasma Level of miRNA-7, miRNA-409 and miRNA-93 as Potential Biomarkers for Colorectal Cancer

Document Type: Research Article

Authors

1 Department of Biology, Faculty of Sciences, Payame Noor University, Tehran, Iran

2 Bonab Islamic Azad University, Bonab, Iran

Abstract

Colorectal cancer (CRC) is among deadliest cancers all over the world. Regarding its high mortality, some researches have focused to discover new applicable diagnosis methods. In this regard, circulatory miRNAs has been received huge consideration as promising biomarkers for early detection of CRC. The study aimed to evaluate the expression level of miRNA-7, miRNA-93, and miRNA-409 in plasma of CRC patients compared to healthy controls. According to the results, miRNA-7 and miRNA-409 were significantly upregulated in plasma of CRC patients (p< 0.05) while miRNA-93 was insignificantly elevated in CRC patients (p> 0.05). Therefore, it seems that upregulation of miRNA-7, miRNA-93, and miRNA-409 is involved in CRC carcinogenesis. Additionally, miRNA-7 and miRNA-409 could be considered as novel potential biomarkers for CRC.

Keywords


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